Takahashi S, Chi X J, Nomura J, Sugaya S, Kita K, Suzuki N
Department of Biochemistry 2, Chiba University School of Medicine, Japan.
J Gravit Physiol. 2000 Jul;7(2):P81-2.
We have reported that human interferon, one of cytokines present in serum, can confer hypomutability on various human cells. On the contrary, we have also reported that serum factors from cancer patients can enhance cell mutability. Therefore, it seems likely that cell mutability is changed by cytokine-like serum factors in our body. It is one of important space problems whether the mutability of human cells is regulated in response to microgravity and hypergravity (gravitational stress). However, there is little information about cell mutability during such stress. In this study, we investigated whether the mutability is changed by exposing cells to human serum factors after gravitational stress.
我们已经报道过，人体干扰素作为血清中存在的细胞因子之一，可使多种人体细胞的突变率降低。相反，我们也报道过癌症患者的血清因子可提高细胞的突变率。因此，我们体内类似细胞因子的血清因子似乎有可能改变细胞的突变率。人体细胞的突变率是否会响应微重力和超重力（重力应激）而受到调节，这是一个重要的空间问题。然而，关于此类应激期间细胞突变率的信息却很少。在本研究中，我们调查了在重力应激后将细胞暴露于人体血清因子是否会改变突变率。
