Hood Donald C
Department of Psychology, Columbia University, New York, New York 10027, USA.
Curr Opin Ophthalmol. 2003 Apr;14(2):78-82. doi: 10.1097/00055735-200304000-00004.
Of the objective (electrophysiological), functional tests of glaucomatous damage, three hold the most promise. Some evidence suggests that the pattern electroretinogram, the photopic negative response of the electroretinogram, and the multifocal visual-evoked potential can detect early glaucomatous damage, damage that may be missed on static automated achromatic perimetry. However, in their current forms, these tests can supplement, but cannot replace, static automated achromatic perimetry. Further, the multifocal visual-evoked potential is the only one of these tests that supplies topographic information about local damage. In addition, we still lack a complete understanding of the relation between these tests and the underlying damage to ganglion cells. In this context, it has recently been suggested that the signal in the multifocal visual-evoked potential response may be linearly related to the loss of ganglion cells. Finally, more information is needed about these tests from longitudinal or prospective studies.
在青光眼性损害的客观（电生理）功能测试中，有三种测试最具前景。一些证据表明，图形视网膜电图、视网膜电图的明视负反应以及多焦视觉诱发电位能够检测出早期青光眼性损害，而这种损害在静态自动无色视野检查中可能会被遗漏。然而，就目前的形式而言，这些测试可以作为补充，但无法取代静态自动无色视野检查。此外，多焦视觉诱发电位是这些测试中唯一能提供局部损害地形图信息的测试。另外，我们对这些测试与神经节细胞潜在损害之间的关系仍缺乏全面的了解。在这种情况下，最近有人提出，多焦视觉诱发电位反应中的信号可能与神经节细胞的丢失呈线性相关。最后，需要从纵向或前瞻性研究中获取更多关于这些测试的信息。
