Xu Dan, Yang Chunhui, Wang Luning
Department of Geriatric Neurology, Chinese PLA General Hospital, 28 Fuxing Road, 100853 Beijing, P.R. China.
Acta Neuropathol. 2003 Jul;106(1):89-91. doi: 10.1007/s00401-003-0706-1. Epub 2003 Apr 15.
To investigate the prevalence and clinico-neuropathological characteristics of cerebral amyloid angiopathy (CAA) in aged Chinese and its relationship to dementia and cerebrovascular lesions, we examined 362 archived brains of elderly with immunohistochemical staining for beta-amyloid peptide and Congo red, Bodian and Luxol fast blue stains. We found that: (1) CAA appeared in 31.7% examined brains without sexual preponderance, and the incidence increased with age; (2) the frontal lobe was most frequently involved in CAA, followed by occipital and parietal lobe; (3) subcortical white matter and cerebellum dentate nucleus areas may also be affected by CAA; (4) CAA has a close relationship to Alzheimer's disease and multiple cerebrovascular lesions; (5) CAA alone may result in dementia.
为研究中国老年人脑淀粉样血管病（CAA）的患病率、临床神经病理学特征及其与痴呆和脑血管病变的关系，我们对362例存档的老年大脑进行了β-淀粉样肽免疫组织化学染色、刚果红染色、博迪安染色和卢克斯尔坚牢蓝染色。我们发现：（1）31.7%的受检大脑出现CAA，无性别差异，且发病率随年龄增长而增加；（2）额叶是CAA最常累及的部位，其次是枕叶和顶叶；（3）皮质下白质和小脑齿状核区域也可能受CAA影响；（4）CAA与阿尔茨海默病和多发性脑血管病变密切相关；（5）单独的CAA可能导致痴呆。
