Krykorková I, Nedvídková J
Prírodovĕdecká fakulta UK, Endokrinologický ústav, Praha.
Cas Lek Cesk. 2003 Feb;142(2):80-3.
Adipocytal hormones resistin and adiponectin and gastric peptide ghrelin are recently discovered hormones, which are considered to take part in energy metabolism regulation. Resistin is expressed in adipose tissue only and its increased levels could cause insulin resistance and thus link obesity with type 2 diabetes. Adiponectin, as well as resistin, are products of genes, expressed in adipose tissue. Adiponectin could prevent development of aterosclerosis and it could play a role in anti-inflammatory reactions. Ghrelin is produced mainly in the stomach. Beside its role in long-term regulation of energy metabolism, it is involved in the short-term regulation of feeding. Main roles of resistin, adiponectin and ghrelin are summarised in the presented overview.
脂肪细胞激素抵抗素、脂联素和胃肽Ghrelin是最近发现的激素，它们被认为参与能量代谢调节。抵抗素仅在脂肪组织中表达，其水平升高会导致胰岛素抵抗，从而将肥胖与2型糖尿病联系起来。脂联素与抵抗素一样，都是在脂肪组织中表达的基因产物。脂联素可以预防动脉粥样硬化的发展，并且在抗炎反应中发挥作用。Ghrelin主要在胃中产生。除了在能量代谢的长期调节中发挥作用外，它还参与进食的短期调节。本文综述了抵抗素、脂联素和Ghrelin的主要作用。
