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[1970 - 2001年支气管源性癌的外科治疗]

[Surgical treatment of bronchogenic carcinoma 1970-2001].

作者信息

Marel M, Skácel Z, Stastný B, Melínová L, Pafko P, Schutzner J, Cermák S, Pospísil R

机构信息

Pneumologická klinika 1. LF UK, Praha-Veleslavín.

出版信息

Cas Lek Cesk. 2003 Feb;142(2):88-92.

Abstract

BACKGROUND

Lung cancer (LC) is a permanent medical and social problem. 5709 patients died in the year 2000 of this disease in Czech Republic. Its incidence in men is 100/100,000 and it shows only small trend to decrease. In women the incidence has reached 22/100,000 and is still rising. The ratio males/females in the whole country is 4:1, in pulmonary department of University hospital Motol is close to 2:1. The optimal way of treatment is a surgery.

METHODS AND RESULTS

From the data about diagnostics and operability in Pneumological Clinic of the 1st Medical Faculty of the Charles University (former 2nd Clinic of Tuberculosis and Respiratory Diseases) and from adequate data obtained from the Pulmonary department of University hospital Motol we can see that the number of operated patients increased from 20% in 1970 to 28% in 2001. When compared two set of patients operated in the period 1985-1990 and 1998-2001 we learned the change of the ratio males/females (from 17:1 to 2:1), lower number of pneumonectomies (from 34% to 31%), lower number of exploratory thoracotomies (from 13% to 5%), decrease of perioperative mortality from 10% do 2%. The percentage of correct clinical when compared to pathological TNM staging was similar in both periods (55% in the period 1985-1990 and 53% in the period 1998-2001). In the article we describe also results of diagnostics, induction and adjuvant treatment and possibilities of the increase of operability of the patients with lung cancer.

CONCLUSIONS

The authors think that despite some improvements in several parameters, the 5-year survival of patients with lung cancer is in our country and the whole world still unsatisfactory. We recommend the revision of current attitude to the screening of lung cancer and we recommend joining the running European-American trials of screening of such patients with the help of low-dose spiral CT.

摘要

背景

肺癌是一个长期存在的医学和社会问题。2000年,捷克共和国有5709人死于该病。其在男性中的发病率为100/10万,且仅有微小的下降趋势。在女性中,发病率已达22/10万且仍在上升。全国男女发病率之比为4:1,在Motol大学医院胸科则接近2:1。最佳治疗方式是手术。

方法与结果

从查理大学第一医学院肺病诊所(原第二结核病与呼吸疾病诊所)的诊断及可手术性数据,以及Motol大学医院胸科获得的相关数据可知,手术患者数量从1970年的20%增至2001年的28%。比较1985 - 1990年和1998 - 2001年两组手术患者,我们发现男女比例发生了变化(从17:1变为2:1),肺切除术数量减少(从34%降至31%),探查性开胸手术数量减少(从13%降至5%),围手术期死亡率从10%降至2%。两个时期正确临床分期与病理TNM分期的百分比相似(1985 - 1990年为55%,1998 - 2001年为53%)。本文还描述了肺癌患者的诊断、诱导和辅助治疗结果以及提高可手术性的可能性。

结论

作者认为,尽管在一些参数上有所改善,但我国乃至全世界肺癌患者的5年生存率仍不尽人意。我们建议修订当前对肺癌筛查的态度,并建议借助低剂量螺旋CT参与正在进行的欧美肺癌筛查试验。

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