一项关于腺苷作为舒芬太尼辅助药物用于分娩期脊髓镇痛的随机双盲评估。
A randomised double-blind evaluation of adenosine as adjunct to sufentanil in spinal labour analgesia.
作者信息
Rane K, Sollevi A, Segerdahl M
机构信息
Department of Anaesthesia and Intensive Care, Danderyd Hospital, Danderyd, Sweden.
出版信息
Acta Anaesthesiol Scand. 2003 May;47(5):601-3. doi: 10.1034/j.1399-6576.2003.00110.x.
BACKGROUND
Intrathecal injection of sufentanil offers labour pain relief of short duration. This double-blind randomised study evaluates if the combination of adenosine to sufentanil could give relevant prolongation (40%) of the duration of sufentanil spinal analgesia.
METHODS
Twenty-five healthy parturients requesting labour analgesia were included. Patients received 10 micro g of sufentanil + 500 micro g of adenosine or 10 micro g of sufentanil intrathecally. Pain intensity and duration of pain relief were assessed.
RESULTS
Pain relief was equal between groups. Duration of analgesia was not increased by adenosine + sufentanil, 99 +/- 54 min, vs. sufentanil, 89 +/- 56 min.
CONCLUSION
Adding 500 micro g of adenosine to 10 micro g of sufentanil could not provide any prolongation of labour pain relief.
背景
鞘内注射舒芬太尼可提供短期的分娩镇痛。这项双盲随机研究评估了腺苷与舒芬太尼联合使用是否能使舒芬太尼脊髓镇痛的持续时间显著延长（40%）。
方法
纳入25名要求分娩镇痛的健康产妇。患者鞘内注射10微克舒芬太尼 + 500微克腺苷或10微克舒芬太尼。评估疼痛强度和镇痛持续时间。
结果
两组之间的镇痛效果相同。腺苷 + 舒芬太尼组的镇痛持续时间未增加，为99 ± 54分钟，而舒芬太尼组为89 ± 56分钟。
结论
在10微克舒芬太尼中添加500微克腺苷不能延长分娩镇痛的时间。
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