Goulart Marília O F, Falkowski Piotr, Ossowski Tadeusz, Liwo Adam
Departamento de Química-CCEN Campus, Universidade Federal de Alagoas, Tabuleiro dos Martins, Maceio, Brazil.
Bioelectrochemistry. 2003 Apr;59(1-2):85-7. doi: 10.1016/s1567-5394(03)00005-7.
Cyclovoltammetric studies were performed with lapachol [2-hydroxy-3-(3-methyl-2-butenyl)-1,4-naphthoquinone], in the absence and presence of oxygen, which aimed to investigate possible oxygen interaction with lapachol and its radical anion. The obtained results clearly indicate the consumption of the semiquinone anion-radicals by oxygen in an EC type reaction, generating the deprotonated form of lapachol and HOO*. The observed generation of reactive oxygen species (ROS) after electron transfer can be related to the mechanism of biological action of lapachol.
在有氧和无氧条件下，对拉帕醇[2-羟基-3-(3-甲基-2-丁烯基)-1,4-萘醌]进行了循环伏安法研究，旨在探究氧气与拉帕醇及其自由基阴离子之间可能的相互作用。所得结果清楚地表明，在EC型反应中，半醌阴离子自由基被氧气消耗，生成拉帕醇的去质子化形式和HOO*。电子转移后观察到的活性氧（ROS）生成可能与拉帕醇的生物作用机制有关。
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