Aula P, von Koskull H
Hum Genet. 1976 May 19;32(2):143-8. doi: 10.1007/BF00291497.
Localization of chromosome breaks in human chromosomes was analyzed in 264 peripheral lymphocyte cultures. Three hundred and sixty-nine chromosome breaks could be exactly localized to a chromosome band or region of the Paris Conference nomenclature. The distribution of breaks in the chromosome regions was found to be nonrandom. Chromosome 3 alone had 23% of the breaks and region 3p2 had 13% of the total breaks. Some other chromosome regions, such as 5p1, 9q1, 14q2, and 16q2 also displayed clustering of breaks. Sex chromosomes had less breaks than expected. Spontaneous chromosome breaks were almost exclusively located in the lightly stained G bands.
在264份外周血淋巴细胞培养物中分析了人类染色体断裂的定位。369个染色体断裂能够精确地定位到巴黎会议命名法中的染色体带或区域。发现染色体区域中断裂的分布是非随机的。仅3号染色体就有23%的断裂，3p2区域占总断裂数的13%。其他一些染色体区域，如5p1、9q1、14q2和16q2也显示出断裂的聚集。性染色体的断裂比预期的少。自发染色体断裂几乎都位于浅染的G带。
