Mattei M G, Ayme S, Mattei J F, Aurran Y, Giraud F
Cytogenet Cell Genet. 1979;23(1-2):95-102. doi: 10.1159/000131309.
The distribution of break points in human chromosomes was analyzed in 15,754 metaphases from 1084 patients. A total of 1099 breaks were specifically localized to a chromosome band or region depicted in the PARIS CONFERENCE (1971) report. The sites of the breaks were very different from the expected random distribution and showed distinct clustering of breaks in some regions. These observations underline the heterogeneity of chromosomal material and furnish comparative data for the study of cytotoxic agents and constitutional chromosomal fragility.
对1084例患者的15754个中期分裂相分析了人类染色体上断裂点的分布。共有1099个断裂点被明确定位到《巴黎会议（1971年）》报告中描述的染色体带或区域。断裂点的位置与预期的随机分布有很大不同，并且在某些区域显示出明显的断裂点聚集。这些观察结果强调了染色体物质的异质性，并为细胞毒性剂和先天性染色体脆性的研究提供了比较数据。
