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对于怀疑有胆总管结石的患者,胆道内镜超声检查结果正常是否可避免进行内镜逆行胰胆管造影?一项对238例患者的前瞻性随访研究。

Do normal findings at biliary endoscopic ultrasonography obviate the need for endoscopic retrograde cholangiography in patients with suspicion of common bile duct stone? A prospective follow-up study of 238 patients.

作者信息

Napoléon B, Dumortier J, Keriven-Souquet O, Pujol B, Ponchon T, Souquet J-C

机构信息

Fédération des Spécialités Digestives, Hôpital Edouard Herriot, Lyon, France.

出版信息

Endoscopy. 2003 May;35(5):411-5. doi: 10.1055/s-2003-38778.

Abstract

BACKGROUND AND STUDY AIMS

Biliary endoscopic ultrasonography (EUS) and endoscopic retrograde cholangiography (ERC) are equally accurate for the diagnosis of common bile duct (CBD) stone. The aim of this prospective 1-year follow-up study was to determine whether normal findings at initial EUS obviated the need for ERC.

PATIENTS AND METHODS

During a 17-month period, all patients referred for biliary EUS because of suspicion of CBD stone, in whom EUS findings were normal were included in the study. Early (1-month) and late (1-year) follow-up details were obtained by mail or telephone. The clinical course and need for ERC were recorded.

RESULTS

238 patients were enrolled. During follow-up, 59 (25 %) patients underwent cholecystectomy, with (n=31) or without (n=28) cholangiography, and 30 patients underwent ERC (13 %). CBD stone was found in 14 (6 %) patients. Of these 30 patients, ERC was done in 15 cases in the first week after EUS, because of persistent suspicion of a CBD stone which was found in 10 patients. The 15 late ERC procedures (carried out more than 1 week after EUS) revealed only one CBD stone. The negative predictive value of EUS for the diagnosis of CBD stones was 95.4 %.

CONCLUSIONS

Patients with suspicion of CBD stones but normal EUS findings have a low risk of needing ERC in a 1-year period.

摘要

背景与研究目的

胆管内镜超声检查(EUS)和内镜逆行胰胆管造影(ERC)在诊断胆总管(CBD)结石方面准确性相当。这项前瞻性1年随访研究的目的是确定初次EUS检查结果正常是否可避免进行ERC。

患者与方法

在17个月期间,所有因怀疑CBD结石而接受胆管EUS检查且EUS检查结果正常的患者均纳入本研究。通过邮件或电话获取早期(1个月)和晚期(1年)随访详情。记录临床病程及进行ERC的必要性。

结果

共纳入238例患者。随访期间,59例(25%)患者接受了胆囊切除术,其中31例进行了胆管造影,28例未进行;30例患者接受了ERC(13%)。14例(6%)患者发现有CBD结石。在这30例患者中,15例在EUS检查后第一周内进行了ERC,原因是持续怀疑有CBD结石,其中10例患者被发现有结石。15例晚期ERC手术(在EUS检查1周后进行)仅发现1例CBD结石。EUS对诊断CBD结石的阴性预测值为95.4%。

结论

怀疑有CBD结石但EUS检查结果正常的患者在1年内需要进行ERC的风险较低。

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