Okamoto Takeshi, Toguchida Junya, Nakamura Takashi
Department of Orthopedic Surgery, Graduate School of Medicine, Institute of Frontier Medical Sciences, Kyoto University.
Nihon Rinsho. 2003 Mar;61(3):432-8.
Huge bone defects that occur as a result of severe trauma or bone and oft tissue tumor are frequently difficult to achieve adequate union. Autogenous or allogeneic bone grafting and reconstruction using biomaterials are the traditional method used to repair bone defects, but it is not easy to reconstruct the structure and strength. Articular cartilage has very limited intrinsic healing capacity. Although numerous attempts to repair full-thickness articular cartilage defects have been conducted, no methods have successfully regenerated long-lasting hyaline cartilage. One of the most promising procedures for bone and cartilage repair is tissue engineering. New techniques of cell therapy for the treatment of bone and cartilage lesions are currently developed. This paper will summarize the current concepts of cell therapy for bone and cartilage repair and its future application.
由于严重创伤或骨与软组织肿瘤导致的巨大骨缺损往往难以实现充分愈合。自体或异体骨移植以及使用生物材料进行重建是修复骨缺损的传统方法，但重建结构和强度并不容易。关节软骨的内在愈合能力非常有限。尽管已经进行了许多修复全层关节软骨缺损的尝试，但尚无方法能够成功再生持久的透明软骨。骨与软骨修复最有前景的方法之一是组织工程。目前正在开发用于治疗骨与软骨损伤的细胞治疗新技术。本文将总结骨与软骨修复细胞治疗的当前概念及其未来应用。
