CD20与多发性骨髓瘤中的小成熟浆细胞形态及t(11;14)相关。
CD20 is associated with a small mature plasma cell morphology and t(11;14) in multiple myeloma.
作者信息
Robillard Nelly, Avet-Loiseau Herve, Garand Richard, Moreau Philippe, Pineau Danielle, Rapp Marie-Josee, Harousseau Jean-Luc, Bataille Regis
机构信息
Laboratory of Hematology and Institut National de la Santé et de la Recherche Médicale (INSERM) U463, Institute of Biology, Nantes, France.
出版信息
Blood. 2003 Aug 1;102(3):1070-1. doi: 10.1182/blood-2002-11-3333. Epub 2003 Apr 17.
CD20 has been reinvestigated in 66 patients with multiple myeloma (MM). Twelve of the patients (18%) expressed CD20, including 5 of 50 patients at diagnosis presenting 100% CD20+ cells. Seven (58%) of 12 CD20+ patients with MM had a small mature plasma cell morphology as opposed to 4 (7%) of 54 with CD20- MM (P =.0001). Of note, 10 (83%) of 12 patients with CD20+ MM had t(11;14) as opposed to 5 of 54 (9%) CD20- patients (P <.001). All the patients with 100% CD20+ cells presented with t(11;14) and 4 of 5 with a small mature plasma cell morphology. Thus, 66% of the patients with t(11;14) expressed CD20, whereas only 4% of the 51 patients lacking such translocation expressed CD20 (P <.0001). In conclusion, CD20 expression is associated with small mature plasma cell morphology and with t(11;14) in patients with MM.
对66例多发性骨髓瘤（MM）患者重新进行了CD20检测。其中12例患者（18%）表达CD20，包括50例诊断时的患者中有5例呈现100% CD20+细胞。12例CD20+的MM患者中有7例（58%）具有小成熟浆细胞形态，而54例CD20-的MM患者中有4例（7%）具有这种形态（P = 0.0001）。值得注意的是，12例CD20+的MM患者中有10例（83%）存在t(11;14)，而54例CD20-的患者中有5例（9%）存在t(11;14)（P < 0.001）。所有100% CD20+细胞的患者均存在t(11;14)，5例中有4例具有小成熟浆细胞形态。因此，66%存在t(11;14)的患者表达CD20，而51例缺乏这种易位的患者中只有4%表达CD20（P < 0.0001）。总之，MM患者中CD20表达与小成熟浆细胞形态以及t(11;14)相关。
Zotero 插件