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胸膜肺炎放线杆菌的fhuA编码一种高铁色素受体，但不受铁的调节。

fhuA of Actinobacillus pleuropneumoniae encodes a ferrichrome receptor but is not regulated by iron.

作者信息

Mikael Leonie G, Srikumar Ramakrishnan, Coulton James W, Jacques Mario

机构信息

Groupe de Recherche sur les Maladies Infectieuses du Porc, Département de pathologie et microbiologie, Faculté de médecine vétérinaire, Université de Montréal, Saint-Hyacinthe, Québec, Canada J2S 7C6.

出版信息

Infect Immun. 2003 May;71(5):2911-5. doi: 10.1128/IAI.71.5.2911-2915.2003.

DOI:10.1128/IAI.71.5.2911-2915.2003
PMID:12704168
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC153255/
Abstract

The swine pathogen Actinobacillus pleuropneumoniae possesses a 75-kDa outer membrane protein (OMP), FhuA, the receptor for ferrichrome, a hydroxamate-type siderophore. Polyclonal serum to FhuA reacted with OMP preparations from 12 serotypes of A. pleuropneumoniae under conditions of iron repletion and restriction. Reverse transcription-PCR confirmed that A. pleuropneumoniae fhuA expression is not upregulated in response to low iron levels. An A. pleuropneumoniae fhuA deletion mutant was generated and showed abolishment of ferrichrome uptake.

摘要

猪胸膜肺炎放线杆菌这种猪病原体拥有一种75千道尔顿的外膜蛋白（OMP），即FhuA，它是异羟肟酸型铁载体高铁色素的受体。在铁充足和铁受限的条件下，针对FhuA的多克隆血清与来自胸膜肺炎放线杆菌12个血清型的OMP制剂发生反应。逆转录聚合酶链反应证实，胸膜肺炎放线杆菌fhuA的表达不会因低铁水平而上调。构建了胸膜肺炎放线杆菌fhuA缺失突变体，该突变体显示出高铁色素摄取功能丧失。

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Infect Immun. 2003 May;71(5):2911-5. doi: 10.1128/IAI.71.5.2911-2915.2003.
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本文引用的文献

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Molecular cloning and characterization of the ferric hydroxamate uptake (fhu) operon in Actinobacillus pleuropneumoniae.胸膜肺炎放线杆菌中铁载体摄取（fhu）操纵子的分子克隆与特性分析
Microbiology (Reading). 2002 Sep;148(Pt 9):2869-2882. doi: 10.1099/00221287-148-9-2869.
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Both transferrin binding proteins are virulence factors in Actinobacillus pleuropneumoniae serotype 7 infection.两种转铁蛋白结合蛋白都是胸膜肺炎放线杆菌7型感染中的毒力因子。
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Actinobacillus pleuropneumoniae iron transport: a set of exbBD genes is transcriptionally linked to the tbpB gene and required for utilization of transferrin-bound iron.胸膜肺炎放线杆菌的铁转运：一组exbBD基因与tbpB基因转录相关联，并且是利用转铁蛋白结合铁所必需的。
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