Narai Satoru, Nagahata Shunichiro
Department of Oral Surgery, Kagawa Medical University, Kagawa, Japan.
Int J Oral Maxillofac Implants. 2003 Mar-Apr;18(2):218-23.
In this study, the removal torques of commercially pure titanium Implants that had been implanted simultaneously with the start of treatment for osteoporosis were compared to those of a group without treatment and a healthy group.
Rats treated by ovariectomy or sham surgery at the age of 12 weeks were used. Twenty-eight days after surgery, the rats treated by ovariectomy were divided into an alendronate-treated group and an untreated (ovariectomy-control) group. At the start of administration of alendronate, a titanium implant was placed in the distal metaphysis of the femur. After 1 month of administration of alendronate and a vehicle, removal torque, the percentage of bone-implant contact (BIC), and parameters of treatment using alendronate were measured.
The removal torque values were 10.1 +/- 1.6 Ncm for the group of osteoporotic rats that had been administered alendronate and 6.4 +/- 1.0 Ncm for the group of osteoporotic rats that did not receive alendronate, indicating that the removal torque was significantly higher in the former group than in the latter group. However, there was no significant difference between the alendronate-treated group and the healthy control group (ie, sham surgery) (9.3 +/- 1.3 Ncm).
These results suggested that implant placement together with treatment of osteoporosis is possible in the ovariectomized rat model.
在本研究中，将与骨质疏松症治疗开始同时植入的商业纯钛种植体的拆除扭矩与未治疗组和健康组的拆除扭矩进行比较。
使用12周龄时接受卵巢切除术或假手术的大鼠。术后28天，将接受卵巢切除术的大鼠分为阿仑膦酸盐治疗组和未治疗（卵巢切除对照）组。在开始给予阿仑膦酸盐时，将一枚钛种植体置于股骨远端干骺端。在给予阿仑膦酸盐和赋形剂1个月后，测量拆除扭矩、骨-种植体接触百分比（BIC）以及使用阿仑膦酸盐的治疗参数。
接受阿仑膦酸盐治疗的骨质疏松大鼠组的拆除扭矩值为10.1±1.6 N·cm，未接受阿仑膦酸盐治疗的骨质疏松大鼠组的拆除扭矩值为6.4±1.0 N·cm，表明前一组的拆除扭矩明显高于后一组。然而，阿仑膦酸盐治疗组与健康对照组（即假手术组）之间无显著差异（9.3±1.3 N·cm）。
这些结果表明，在去卵巢大鼠模型中，植入种植体并同时治疗骨质疏松症是可行的。
