Habib S S, Aslam M, Naveed A K, Sattar A
Department of Physiology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Pak Med Assoc. 2003 Feb;53(2):54-9.
To measure lipoprotein (Lp)(a) levels in people with diabetes mellitus (DM) and to see if there is any difference in Lp(a) levels between diabetics with good glycaemic control and those with poor glycaemic control.
Sixty subjects with DM and thirty healthy individuals were studied. Fasting blood samples were analyzed for glucose, glycosylated hemoglobin, Serum total cholesterol, triglycerides, low density lipoproteins, high density lipoproteins and Lp(a).
A non significant difference was found between the lipid profile of normal individuals and subjects with DM with a good glycemic control. Lp(a) levels were significantly raised in diabetics. The difference in Lp(a) levels between well controlled and poorly controlled diabetics was non significant. In the control group 23.4% of individuals had high risk levels of Lp(a) while it was 46.7 % for people with DM.
Glycaemic control improves lipid profile positively in diabetics and may even lead to near normalization of lipoprotein concentrations. Diabetics have elevated levels of Lp(a) and the difference in Lp(a) levels between well controlled and poorly controlled diabeticsts is non-significant.
测量糖尿病患者的脂蛋白（Lp）（a）水平，并观察血糖控制良好的糖尿病患者与血糖控制不佳的糖尿病患者之间Lp（a）水平是否存在差异。
对60名糖尿病患者和30名健康个体进行研究。对空腹血样进行葡萄糖、糖化血红蛋白、血清总胆固醇、甘油三酯、低密度脂蛋白、高密度脂蛋白和Lp（a）分析。
血糖控制良好的糖尿病患者与正常个体的血脂谱之间未发现显著差异。糖尿病患者的Lp（a）水平显著升高。血糖控制良好和控制不佳的糖尿病患者之间Lp（a）水平的差异不显著。在对照组中，23.4%的个体Lp（a）水平处于高风险范围，而糖尿病患者中这一比例为46.7%。
血糖控制可使糖尿病患者的血脂谱得到积极改善，甚至可能使脂蛋白浓度接近正常水平。糖尿病患者的Lp（a）水平升高，血糖控制良好和控制不佳的糖尿病患者之间Lp（a）水平的差异不显著。
