Olsson Lennart
Institut für Spezielle Zoologie und Evolutionsbiologie mit Phyletischem Museum, Friedrich-Schiller-Universität Jena, Jena, Germany.
Int J Dev Biol. 2003;47(2-3):171-6.
This intensive course, designed for advanced undergraduates and beginning graduate students, was first taught in 1995 at Uppsala University, Sweden, and consists of a half-semester (8-9 weeks) of daily lecture and laboratory sessions covering a broad range of topics and giving an overview of developmental biology and some of its applications. The labs introduce students to a diverse assortment of model systems. The course goals are to present a comparative view of animal development (gametogenesis, fertilization, gastrulation, neurulation, organogenesis), followed by lectures on cellular and molecular mechanisms that regulate development, such as induction mechanisms, cell adhesion and migration, cell-matrix interactions and genomic imprinting. The development of complex systems, such as the nervous system, limbs and flowers, is emphasized, including aspects such as malformations, homeosis and mutant analysis, reproduction and fertility problems, and the connection between development and cancer. Model organisms are emphasized, but evolutionary aspects receive due attention. Typically, during the first 5 weeks, a day begins with lectures in the morning and ends with labs or demonstrations and seminars in the afternoon. Wednesday afternoons are "free" to give time for reading. A theory test is taken at the end of this period. Then, students do supervised research for 3 weeks to give them a feel for what it is like to do "real science." Finally, students present oral and written reports on their projects. This is the only course students enroll in during this portion of the semester, so they are expected to devote full effort to it.
本强化课程面向高年级本科生和低年级研究生，1995年首次在瑞典乌普萨拉大学授课，为期半学期（8 - 9周），每日安排讲座和实验课，涵盖广泛主题，概述发育生物学及其一些应用。实验课让学生接触各种各样的模型系统。课程目标是呈现动物发育的比较视角（配子发生、受精、原肠胚形成、神经胚形成、器官发生），随后讲解调节发育的细胞和分子机制，如诱导机制、细胞黏附与迁移、细胞 - 基质相互作用和基因组印记。重点强调复杂系统的发育，如神经系统、四肢和花朵，包括畸形、同源异形和突变分析、生殖与生育问题以及发育与癌症之间的联系等方面。课程着重介绍模式生物，但也适当关注进化方面。通常，在前5周，每天上午开始上课，下午以实验、演示或研讨会结束。周三下午“空闲”，以便学生有时间阅读。在此阶段结束时进行理论测试。然后，学生进行3周的导师指导研究，让他们体验“真正的科学”是什么样的。最后，学生就自己的项目进行口头和书面报告。这是学生在本学期这一阶段唯一选修的课程，因此期望他们全力以赴。
