Benowitz N L, Jones R T, Lerner C B
J Clin Endocrinol Metab. 1976 May;42(5):938-41. doi: 10.1210/jcem-42-5-938.
Six hospitalized volunteer male subjects were given insulin, 0.15 U/kg, before and after 14 days of administration of delta-9-tetrahydrocannabinol (THC) at a dose of 210 mg/day. A diminished maximal serum human growth hormone (GH) increase followed the prolonged THC ingestion. The mean maximal GH response was: 52.6 ng/ml +/- 8.7 (+/-SE) before THC and 18.8 ng/ml +/- 6.7 (+/-SE) during THC, P less than 0.01; corresponding cortisol responses were 20.1 mug/dl +/- 3.0 before THC and 10.0 mug/dl +/- 1.1 during THC, P less than 0.05. The data suggest suppression of the hypothalamic-pituitary axis after prolonged high dose THC use. This is consistent with other reported endocrine effects of marijuana in man.
六名住院的男性志愿者在每天服用210毫克δ-9-四氢大麻酚（THC）14天前后，均接受了0.15单位/千克的胰岛素注射。长期摄入THC后，血清中人类生长激素（GH）的最大增幅有所减小。GH的平均最大反应为：服用THC前为52.6纳克/毫升±8.7（±标准误），服用THC期间为18.8纳克/毫升±6.7（±标准误），P<0.01；相应的皮质醇反应在服用THC前为20.1微克/分升±3.0，服用THC期间为10.0微克/分升±1.1，P<0.05。数据表明，长期高剂量使用THC后，下丘脑-垂体轴受到抑制。这与其他报道的大麻对人体内分泌的影响一致。
