将MTA家族与乳腺癌联系起来的另一个纽带。

Another tie that binds the MTA family to breast cancer.

作者信息

Kumar Rakesh

机构信息

Department of Molecular and Cellular Oncology, The University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA.

出版信息

Cell. 2003 Apr 18;113(2):142-3. doi: 10.1016/s0092-8674(03)00274-5.

DOI:10.1016/s0092-8674(03)00274-5

PMID:12705862

Abstract

In this issue of Cell, demonstrate that MTA3 is an estrogen-dependent component of the NuRD complex and identify the Snail gene as its direct target. ER signaling upregulates MTA3 levels to negatively modulate Snail-mediated repression of E-cadherin. These findings may explain how ER status controls epithelial-to-mesenchymal transition in human breast tumors.

摘要

在本期《细胞》杂志中，研究表明MTA3是核小体重塑去乙酰化酶（NuRD）复合物中雌激素依赖性成分，并将Snail基因鉴定为其直接靶点。雌激素受体（ER）信号上调MTA3水平，以负向调节Snail介导的E-钙黏蛋白抑制。这些发现可能解释了ER状态如何控制人类乳腺肿瘤中的上皮-间质转化。