Cremers Bodo, Schmidt Kathrin I, Maack Christoph, Schäfers Hans Joachim, Böhm Michael
Medizinische Klinik und Poliklinik, Innere Medizin III, Universitätskliniken des Saarlandes, 66421 Homburg, Germany.
Eur J Pharmacol. 2003 Apr 25;467(1-3):169-71. doi: 10.1016/s0014-2999(03)01600-5.
Although there are some data on the cardiovascular profile of bupropion, a non-nicotine-based pharmacotherapy for smoking cessation, detailed studies of its specifically cardiac effects are lacking. In particular, the direct action of this agent on human myocardial contractility is not known. Therefore, we investigated the effects of bupropion on human cardiac tissue in vitro. Our results suggest that bupropion exerts indirect sympathomimetic activity producing positive inotropic effects in human myocardium most probably by catecholamine release.
