IJsselstijn M, Kaiser J, van Delft F L, Schoemaker H E, Rutjes F P J T
Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, NL 6525 ED Nijmegen, The Netherlands.
Amino Acids. 2003 Apr;24(3):263-6. doi: 10.1007/s00726-002-0408-3.
Novel synthetic procedures for the modification of non-proteinogenic acetylene-containing amino acids have been developed. The functionalization either proceeds via zinc/copper-mediated introduction of alkyl substituents, or via tungsten-catalyzed ring-closing alkyne metathesis reactions.
已开发出用于修饰非蛋白原性含乙炔氨基酸的新型合成方法。官能化反应要么通过锌/铜介导的烷基取代基引入来进行，要么通过钨催化的关环炔烃复分解反应来进行。
