Louisot P, Richard M, Gateau O
Ann Biol Clin (Paris). 1976;34(4):243-53.
Catalysing the transfer of oses and ose derivatives on various accepters, glucosyltransferases are of increasing importance in biology and pathology. Their sub-cellular localisation is now known together with the physico-chemical parameters of their activity and the importance of polyprenic intermediates. The first phenomenological studies concerning them are in favour of a mechanism of Bi-Bi type. For example, they may play a role in mucoviscidosis, virus diseases, vaccination and arthrosis.
葡糖基转移酶可催化各种受体上的糖和糖衍生物的转移,在生物学和病理学中具有越来越重要的意义。现在已知它们的亚细胞定位以及其活性的物理化学参数和多萜烯中间体的重要性。关于它们的首批现象学研究支持双底物双产物类型的机制。例如,它们可能在粘多糖病、病毒疾病、疫苗接种和关节病中发挥作用。