前列腺素/SV40 T抗原转基因大鼠前列腺中与年龄相关的组织病理学发现：致癌物或睾酮治疗的影响缺失
Age-dependent histopathological findings in the prostate of probasin/SV40 T antigen transgenic rats: lack of influence of carcinogen or testosterone treatment.
作者信息
Cho Young-Man, Takahashi Satoru, Asamoto Makoto, Suzuki Shugo, Inaguma Shingo, Hokaiwado Naomi, Shirai Tomoyuki
机构信息
Department of Experimental Pathology and Tumor Biology, Nagoya City University Graduate School of Medical Sciences, 1 Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467-8601.
出版信息
Cancer Sci. 2003 Feb;94(2):153-7. doi: 10.1111/j.1349-7006.2003.tb01412.x.
Abstract
Sequential changes in the phenotype of prostatic lesions and the impact of additional carcinogen treatment or castration on development and progression of prostate cancers were examined in probasin/simian virus 40 (SV40) T antigen transgenic (TG) rats. Non-invasive prostate adenocarcinomas were evident in all lobes at 15 weeks of age. Invasive tumors were limited to the anterior lobe at this time point and were found in all lobes in an age-dependent manner thereafter. No metastasis was apparent at any age. Additional carcinogen treatment or castration did not enhance progression or generate selective growth of hormone-independent prostate cancer cells. These results suggest that our TG rats are suitable for clarification of mechanisms in early stages of prostate carcinogenesis, that is, from prostatic intraepithelial neoplasia (PIN) to non-invasive and then invasive lesions.
摘要
在前列腺素/猿猴病毒40（SV40）T抗原转基因（TG）大鼠中，研究了前列腺病变表型的顺序变化以及额外的致癌物处理或去势对前列腺癌发生和发展的影响。15周龄时，所有叶均出现非侵袭性前列腺腺癌。此时侵袭性肿瘤仅限于前叶，此后以年龄依赖性方式在所有叶中出现。在任何年龄均未发现转移。额外的致癌物处理或去势并未促进进展或产生激素非依赖性前列腺癌细胞的选择性生长。这些结果表明，我们的TG大鼠适用于阐明前列腺癌发生早期阶段的机制，即从前列腺上皮内瘤变（PIN）到非侵袭性然后侵袭性病变的过程。
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