Dunphy Cherie H, van Deventer Hendrik W, Carder Kathryn J, Rao Kathleen W, Dent Georgette A
Department of Pathology & Laboratory Medicine, Division of Hematopathology, University of North Carolina, Chapel Hill 27599-7525, USA.
Arch Pathol Lab Med. 2003 May;127(5):610-3. doi: 10.5858/2003-127-0610-MBALLW.
The translocation t(14;18)(q32;q21) is most commonly associated with follicular lymphoma but has also been described in acute lymphoblastic leukemia (ALL) of B-cell origin. Although these ALL cases have had a pre-pre-B, pre-B, or mature B-cell immunophenotype and L2 or L3 morphology, all have been associated with an abnormality of 8q24. In fact, 91% (10 of 11) have been associated with t(8;22) or t(8;14), marker chromosomes for Burkitt-type ALL. The other case was associated with del(8)(q24). Thus, Burkitt-type ALL may have various immunophenotypes and morphology when associated with t(14;18). We describe a case of mature B-cell ALL associated with t(14;18) and t(8;9)(q24;p13). The morphology was suggestive but not entirely characteristic of the L3 subtype. However, on the basis of the cytogenetic findings and the review of the literature, perhaps this case represents a variant of Burkitt-type ALL, which would be important to recognize for prognostic and therapeutic purposes. We describe our findings and review the literature to heighten awareness of this group of ALLs associated with t(14;18). Additional cases need to be accrued and documented to determine the significance of an associated abnormality of 8q24 in this setting.
易位t(14;18)(q32;q21)最常与滤泡性淋巴瘤相关，但也见于B细胞起源的急性淋巴细胞白血病（ALL）。尽管这些ALL病例具有前前B细胞、前B细胞或成熟B细胞免疫表型以及L2或L3形态，但均与8q24异常有关。事实上，91%（11例中的10例）与t(8;22)或t(8;14)相关，这是伯基特型ALL的标记染色体。另一例与del(8)(q24)相关。因此，伯基特型ALL与t(14;18)相关时可能有多种免疫表型和形态。我们描述了1例与t(14;18)和t(8;9)(q24;p13)相关的成熟B细胞ALL病例。其形态提示为L3亚型，但并不完全具有特征性。然而，根据细胞遗传学结果和文献回顾，或许该病例代表了伯基特型ALL的一种变异型，认识到这一点对于预后和治疗目的很重要。我们描述了我们的发现并回顾文献以提高对这组与t(14;18)相关的ALL的认识。需要积累和记录更多病例以确定在此情况下8q24相关异常的意义。
