Bernhard W F, Poirier V, LaFarge C C, Carr J G
J Thorac Cardiovasc Surg. 1975 Nov;70(5):880-95.
Surgical patients who cannot be weaned from cardiopulmonary bypass during operation or who develop balloon-dependent left ventricular failure postoperatively are now considered unsavable. However, in those with potentially reversible ventricular dysfunction, recovery might be possible if an improved means of temporary circulatory support were available. Towards this end, a pneumatically actuated, left ventricular assist pump was developed and evaluated in 20 consecutive calf experiments. The device, containing a flexible polyurethane pumping chamber, was positioned on the chest wall and connected to the left ventricular apex and descending thoracic aorta by two Dacron valved conduits (xenograft valves). All animals survived a 14 to 30 day pumping interval, and 7 underwent successful removal of the device by division of the Dacron conduits below skin level. As a prelude to human investigation, pumps were implanted during a series of routine autopsies through midline sternotomy incison. The device was positioned on the right anterolateral chest wall, with two valved conduits traversing the mediastinum to connect the pump to the left ventricular apex and ascending aorta.
在手术过程中无法脱离体外循环或术后发生依赖球囊的左心室衰竭的外科患者，目前被认为无法救治。然而，对于那些具有潜在可逆性心室功能障碍的患者，如果有改进的临时循环支持手段，恢复仍有可能。为此，研制了一种气动驱动的左心室辅助泵，并在连续20例小牛实验中进行了评估。该装置包含一个柔性聚氨酯泵腔，置于胸壁上，并通过两根带瓣涤纶导管（异种移植瓣膜）与左心室心尖和胸降主动脉相连。所有动物均存活了14至30天的泵血期，7只动物通过在皮肤水平以下切断涤纶导管成功移除了该装置。作为人体研究的前奏，在一系列常规尸检过程中通过正中胸骨切开术植入了泵。该装置置于右前外侧胸壁，两根带瓣导管穿过纵隔将泵与左心室心尖和升主动脉相连。
