N-halo derivatives III: stabilization of nitrogen-chlorine bond in N-chloroamino acid derivatives.
作者信息
Kaminski J J, Bodor N, Higuchi T
出版信息
J Pharm Sci. 1976 Apr;65(4):553-7. doi: 10.1002/jps.2600650418.
PMID:1271254
Abstract
The chlorination of alpha-amino acids and their related derivatives was investigated. A kinetic study of the stability of these N-chlorinated products led to an elucidation of the factors that significantly influence the stability and reactivity of the nitrogen-chlorine bond in these N-chloramines. From the kinetic investigations, a series of low chlorine potential, soft antimicrobial N-chloramines was developed based on derivatives of alpha-aminoisobutyric acid and related compounds.
摘要
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