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可生物吸收自膨胀编织支架的力学性能及体外降解

Mechanical properties and in vitro degradation of bioabsorbable self-expanding braided stents.

作者信息

Nuutinen Juha-Pekka, Clerc Claude, Reinikainen Raija, Törmälä Pertti

机构信息

Institute of Biomaterials, Tampere University of Technology, PO Box 589, FIN-33101 Tampere, Finland.

出版信息

J Biomater Sci Polym Ed. 2003;14(3):255-66. doi: 10.1163/156856203763572707.

Abstract

The aim of this study was to characterize the mechanical and self-expansion properties of braided bioabsorbable stents. In total four different stents were manufactured from PLLA fibres using a braiding technique. The changes in radial pressure stiffness and diameter recovery of the stents were determined initially, and after insertion and release from a delivery device. The braided stents were compared to three commercially available metallic braided stents. The changes in physical and mechanical properties of the PLLA fibres and stents during in vitro degradation were investigated. After release from the delivery device, the PLLA stents did not fully recover to their original diameter. The radial pressure stiffness of the bioabsorbable stents was similar to that of the metallic stents. The in vitro degradation study showed that the stents would keep at least half of their initial radial pressure stiffness for more than 22 weeks.

摘要

本研究的目的是表征编织型生物可吸收支架的力学性能和自膨胀特性。总共使用编织技术由聚乳酸(PLLA)纤维制造了四种不同的支架。首先测定了支架在插入和从输送装置释放前后的径向压力刚度和直径恢复情况。将编织型支架与三种市售金属编织型支架进行了比较。研究了PLLA纤维和支架在体外降解过程中的物理和力学性能变化。从输送装置释放后,PLLA支架并未完全恢复到其原始直径。生物可吸收支架的径向压力刚度与金属支架相似。体外降解研究表明,支架在超过22周的时间内将保持其初始径向压力刚度的至少一半。

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