一名甲状腺功能减退患者体内起源于单克隆的产生促甲状腺激素的多激素性垂体瘤。
A plurihormonal TSH-producing pituitary tumor of monoclonal origin in a patient with hypothyroidism.
作者信息
Ma Wenbin, Ikeda Hidetoshi, Watabe Noriaki, Kanno Mitsunobu, Yoshimoto Takashi
机构信息
Division of Neurosurgery, Tohoku Graduate School of Medicine, Sendai, Miyagi, Japan.
出版信息
Horm Res. 2003;59(5):257-61. doi: 10.1159/000070227.
OBJECTIVE
A clinicopathological and clonal study of a pituitary tumor was made in a 26-year-old woman with chronic thyroiditis to differentiate TSH-producing adenoma from TSH hyperplasia.
METHODS
Tumor specimens were subjected to histopathological study and clonal analysis (HUMARA).
RESULTS
Immunohistochemical examination disclosed TSH-beta, PRL, GH, ACTH, FSH-beta, LH-beta, and alpha-subunit production in the adenoma cells. These heterogeneous phenotypes are characteristic of both thyrotroph hyperplasia and plurihormonal TSH-producing adenoma. However, the HUMARA method demonstrated monoclonality of the tumor cells.
CONCLUSION
Monoclonality of the tumor cells proved that the pituitary tumor was plurihormonal TSH-producing adenoma, not TSH hyperplasia.
目的
对一名患有慢性甲状腺炎的26岁女性的垂体肿瘤进行临床病理和克隆研究，以区分促甲状腺激素分泌性腺瘤与促甲状腺激素增生。
方法
对肿瘤标本进行组织病理学研究和克隆分析（人类雄激素受体基因多态性分析，HUMARA）。
结果
免疫组化检查显示腺瘤细胞分泌促甲状腺激素-β、催乳素、生长激素、促肾上腺皮质激素、促卵泡激素-β、促黄体生成素-β和α亚基。这些异质性表型是促甲状腺细胞增生和多激素分泌促甲状腺激素分泌性腺瘤的特征。然而，HUMARA方法显示肿瘤细胞为单克隆性。
结论
肿瘤细胞的单克隆性证明该垂体肿瘤是多激素分泌促甲状腺激素分泌性腺瘤，而非促甲状腺激素增生。
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