Yamakita N, Ikeda T, Murai T, Komaki T, Hirata T, Miura K
Department of Internal Medicine, Matsunami General Hospital, Gifu.
Intern Med. 1995 Nov;34(11):1055-60. doi: 10.2169/internalmedicine.34.1055.
A 46-year-old woman with incidentally discovered thyrotropin (TSH)-producing pituitary adenoma showed endocrine data which was consistent with TSH-producing pituitary tumor. However, she showed only slight hyperthyroidism and the oversecretion and autonomous secretion of TSH from the tumor seemed to be limited from the results of several endocrine examinations. Immunohistochemical examination revealed that not only TSH-beta and TSH-alpha but also prolactin and growth hormone synthesizing cells were present in the tumor tissue. Pituitary-transcription activator 1 (Pit-1) immunoreactivity was also detected in the adenoma cell nuclei. It was conceivable that the presented TSH-producing adenoma clinically located close to the non-functioning adenoma and Pit-1 may have played an important role in the multidirectional differentiation or development of this tumor.
一名46岁女性偶然发现患有促甲状腺激素（TSH）分泌型垂体腺瘤，其内分泌数据与TSH分泌型垂体瘤相符。然而，她仅表现出轻微的甲状腺功能亢进，多项内分泌检查结果显示肿瘤分泌过量及自主分泌TSH的情况似乎有限。免疫组化检查发现肿瘤组织中不仅存在TSH-β和TSH-α，还存在催乳素和生长激素合成细胞。腺瘤细胞核中也检测到垂体转录激活因子1（Pit-1）免疫反应性。可以推测，所呈现的TSH分泌型腺瘤在临床上与无功能腺瘤位置相近，且Pit-1可能在该肿瘤的多向分化或发展中发挥了重要作用。
