Tamiolakis D, Papadopoulos N, Lambropoulou M, Kotini A, Simopoulos C
Department of Cytology, Regional Hospital of Alexandroupolis, Greece.
Minerva Med. 2003 Feb;94(1):51-6.
Atypical and anaplastic meningiomas tend to recur and to invade adjacent brain, bone, and skin. They can also metastasize to extracranial organs such as the lung, liver, or bone causing death. The classic genetic abnormality is loss in chromosome 22. Recent reports have indicated that allelic deletion of chromosome 1p is associated with malignant progression of meningiomas.
Cytogenetic analysis of 4 meningiomas was performed using double target fluorescent in situ hybridization and focusing on chromosomes 1 and 22. The meningioma series included 4 patients whose tumors were histologically benign.
One patient's tumor had recurred. FISH was performed on 500 nuclei/tumors. All our cases showed a loss of chromosome 22q while only 1 meningioma showed an additional loss of chromosome 1p, and this was the recurred one.
The results of this study support the existence of tumor suppressor gene(s) on 1p associated with recurrence in meningiomas and suggest that status of chromosome 1p by FISH may assist physicians in predicting prognosis of patients affected by this tumor. However more in-vestigation is needed in this direction, as our re-sults refer to a small number of subjects studied.
非典型性和间变性脑膜瘤易于复发并侵犯邻近的脑、骨和皮肤。它们还可转移至颅外器官，如肺、肝或骨，从而导致死亡。经典的基因异常是22号染色体缺失。最近的报告表明，1p染色体的等位基因缺失与脑膜瘤的恶性进展相关。
使用双靶点荧光原位杂交技术对4例脑膜瘤进行细胞遗传学分析，并聚焦于1号和22号染色体。脑膜瘤系列包括4例组织学上为良性肿瘤的患者。
1例患者的肿瘤复发。对500个核/肿瘤进行了荧光原位杂交检测。我们所有的病例均显示22q染色体缺失，而只有1例脑膜瘤显示1p染色体额外缺失，且此例为复发病例。
本研究结果支持1p上存在与脑膜瘤复发相关的肿瘤抑制基因，并表明荧光原位杂交检测的1p染色体状态可能有助于医生预测受此肿瘤影响患者的预后。然而，由于我们的结果涉及的研究对象数量较少，因此在这个方向上还需要更多的研究。
