Lobmann Ralf, Schultz Gregory, Lehnert Hendrik
Klinik für Endokrinologie und Stoffwechselkrankheiten, Universität Magdeburg.
Med Klin (Munich). 2003 Apr 25;98(5):292-301. doi: 10.1007/s00063-003-1260-2.
The diabetic foot syndrome represents a considerable problem of health care. Due to the systemic character of diabetes mellitus, disturbances on the molecular level of wound healing are assumed.
Growth factors and proteases affect the process of normal wound healing, and changes of their activity are relevant to the pathogenesis of the chronic wound. First studies describe the transition of a diabetic foot lesion to a nonhealing chronic wound on the molecular and cellular level.
This review reports on the current status of research and new implications for the treatment of diabetic foot syndrome.
糖尿病足综合征是医疗保健领域的一个重大问题。由于糖尿病的全身性特征，推测伤口愈合的分子水平存在紊乱。
生长因子和蛋白酶影响正常伤口愈合过程，其活性变化与慢性伤口的发病机制相关。最初的研究在分子和细胞水平描述了糖尿病足病变向不愈合慢性伤口的转变。
本综述报告了糖尿病足综合征的研究现状及治疗的新启示。
