Obrebowska Anna, Sibila-Owczarska Agnieszka, Sajdak Stefan
Kliniki Ginekologii Operacyjnej, GPSK AM w Poznaniu.
Ginekol Pol. 2002 Nov;73(11):1109-12.
Tamoxifen is one of most common drugs for breast cancer therapy. But its weak estrogenic activity in endometrium can be the source of different abnormalities including even endometrial cancer.
The aim of this clinical trial was to compare ultrasound scan results, hysteroscopy and pathomorphological findings of tamoxifen treated patients with breast cancer who complained of bleeding.
Analyzed group consisted of 10 patients treated for abnormal endometrium during breast cancer tamoxifen therapy.
Among 10 examined women 7 presented no pathological changes, there was 1 case of simple benign hypertrophy and 2 cases of endometrial polyps.
There is no exact correlation between ultrasound scan results and pathomorphological findings in patients treated with tamoxifen for of breast cancer. Transvaginal ultrasound examination is not efficient screening test for endometrial abnormalities during tamoxifen therapy.
