Turbes C C
Department of Biomedical Sciences, Creighton University, USA.
Biomed Sci Instrum. 2003;39:289-99.
Earlier work concerning regeneration of synaptic connection had been studied primarily in amphibia. Sperry and Miner and Stevens showed that functional regeneration of synapses followed sectioning and anastomosis of the central process of the dorsal root of one side to the proximal stump of the dorsal root of the opposite. A number of studies have shown that the dorsal roots and dorsal columns of mammals have adequate regenerative capacities. There is no functional or morphologic evidence for reestablishment of synaptic connections reported in the mammalian studies. A number of authors have reported that regenerating dorsal root fibers are confronted with a barrier at the neutilemmal-glial junctions. Previous studies have shown that peripheral nerve fibers inserted into the spinal cord grow profusely. Theorizing that regenerating dorsal root fibers would grow and reestablish synaptic connection more readily, it was decided to insert the neurilemmal portion- including Schwann cells- of the dorsal roots into the spinal cord to the depths of the gray columns.
早期关于突触连接再生的研究主要在两栖动物中进行。斯佩里、迈纳和史蒂文斯表明，在将一侧背根的中枢突切断并与另一侧背根的近端残端吻合后，突触会发生功能性再生。许多研究表明，哺乳动物的背根和背柱具有足够的再生能力。在哺乳动物研究中，没有关于突触连接重建的功能或形态学证据报道。一些作者报告说，再生的背根纤维在神经膜 - 神经胶质交界处遇到障碍。先前的研究表明，插入脊髓的外周神经纤维会大量生长。基于再生的背根纤维会更容易生长并重建突触连接这一理论，决定将背根的神经膜部分（包括施万细胞）插入脊髓至灰质柱深处。
