Cohly Hari H P, Buckley Robert C, Pecunia Richard, Das Suman K
Division of Plastic Surgery, Department of Surgery, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216, USA.
Biomed Sci Instrum. 2003;39:446-53.
Heterotopic bone formation (HBF), an ill-defined phenomenon, refers to the formation of bone in tissue that normally does not ossify. Two existing theories to explain HBF are that two cellular entities, one from the bone and the other from the muscle or fascia (two cell types) are involved, and that stem cell responds to a factor induced by trauma (one cell + factor). In our report, the HBF in a patient's vertical abdominal wound was possibly due to IEL, a stem cell, which is stimulated by a factor from xiphoid when it is traumatized by surgical incision. After 28 days' culture rat tissue specimens from the xiphoid, upper gastrointestinal tract, pubis and bladder exhibited macroscopic mineralization with cellular infiltration, a paradigm of 2-dimensional BF. Characteristically, pubis + bladder, xiphoid + ileum and xiphoid + duodenum showed 2-dimensional BF by as early as 5 days. Thus, it appears that both theories of HBF may be valid.
异位骨形成（HBF）是一种定义不明确的现象，指的是在正常情况下不会发生骨化的组织中形成骨。目前有两种理论来解释HBF，一种理论认为涉及两种细胞实体，一种来自骨，另一种来自肌肉或筋膜（两种细胞类型）；另一种理论认为干细胞对创伤诱导的因子作出反应（一种细胞+因子）。在我们的报告中，一名患者腹部垂直伤口处的HBF可能是由于肠上皮内淋巴细胞（IEL），一种干细胞，在受到手术切口创伤时受到来自剑突的因子刺激所致。对剑突、上消化道、耻骨和膀胱的大鼠组织标本进行28天培养后，出现了伴有细胞浸润的宏观矿化，这是二维骨形成的范例。其特点是，耻骨+膀胱、剑突+回肠和剑突+十二指肠最早在5天时就出现了二维骨形成。因此，似乎HBF的两种理论都可能是正确的。
