童年期性虐待和创伤后应激障碍女性海马体结构与功能缺陷的磁共振成像和正电子发射断层显像研究

MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder.

作者信息

Bremner J Douglas, Vythilingam Meena, Vermetten Eric, Southwick Steven M, McGlashan Thomas, Nazeer Ahsan, Khan Sarfraz, Vaccarino L Viola, Soufer Robert, Garg Pradeep K, Ng Chin K, Staib Lawrence H, Duncan James S, Charney Dennis S

机构信息

Department of Psychiatry and Behavioral Sciences, Emory Clinical Neuroscience Research Unit, Emory University School of Medicine, 1256 Briarcliff Road, Atlanta, GA 30306, USA.

出版信息

Am J Psychiatry. 2003 May;160(5):924-32. doi: 10.1176/appi.ajp.160.5.924.

DOI:10.1176/appi.ajp.160.5.924

PMID:12727697

Abstract

OBJECTIVE

Animal studies have suggested that early stress is associated with alterations in the hippocampus, a brain area that plays a critical role in learning and memory. The purpose of this study was to measure both hippocampal structure and function in women with and without early childhood sexual abuse and the diagnosis of posttraumatic stress disorder (PTSD).

METHOD

Thirty-three women participated in this study, including women with early childhood sexual abuse and PTSD (N=10), women with abuse without PTSD (N=12), and women without abuse or PTSD (N=11). Hippocampal volume was measured with magnetic resonance imaging in all subjects, and hippocampal function during the performance of hippocampal-based verbal declarative memory tasks was measured by using positron emission tomography in abused women with and without PTSD.

RESULTS

A failure of hippocampal activation and 16% smaller volume of the hippocampus were seen in women with abuse and PTSD compared to women with abuse without PTSD. Women with abuse and PTSD had a 19% smaller hippocampal volume relative to women without abuse or PTSD.

CONCLUSIONS

These results are consistent with deficits in hippocampal function and structure in abuse-related PTSD.

摘要

目的

动物研究表明，早期应激与海马体的改变有关，海马体是大脑中一个在学习和记忆中起关键作用的区域。本研究的目的是测量有或没有童年期性虐待且被诊断为创伤后应激障碍（PTSD）的女性的海马体结构和功能。

方法

33名女性参与了本研究，包括有童年期性虐待和PTSD的女性（N = 10）、有虐待但无PTSD的女性（N = 12）以及无虐待或PTSD的女性（N = 11）。对所有受试者进行磁共振成像测量海马体体积，对有和无PTSD的受虐女性在进行基于海马体的言语陈述性记忆任务时，使用正电子发射断层扫描测量海马体功能。