Visse Robert, Nagase Hideaki
Kennedy Institute of Rheumatology Division, Faculty of Medicine, Imperial College London, 1 Aspenlea Rd, London W6 8LH, UK.
Circ Res. 2003 May 2;92(8):827-39. doi: 10.1161/01.RES.0000070112.80711.3D.
Matrix metalloproteinases (MMPs), also designated matrixins, hydrolyze components of the extracellular matrix. These proteinases play a central role in many biological processes, such as embryogenesis, normal tissue remodeling, wound healing, and angiogenesis, and in diseases such as atheroma, arthritis, cancer, and tissue ulceration. Currently 23 MMP genes have been identified in humans, and most are multidomain proteins. This review describes the members of the matrixin family and discusses substrate specificity, domain structure and function, the activation of proMMPs, the regulation of matrixin activity by tissue inhibitors of metalloproteinases, and their pathophysiological implication.
基质金属蛋白酶（MMPs），也被称为基质溶素，可水解细胞外基质的成分。这些蛋白酶在许多生物学过程中发挥核心作用，如胚胎发育、正常组织重塑、伤口愈合和血管生成，以及在动脉粥样硬化、关节炎、癌症和组织溃疡等疾病中。目前已在人类中鉴定出23个MMP基因，且大多数是多结构域蛋白。本综述描述了基质溶素家族的成员，并讨论了底物特异性、结构域结构与功能、前MMPs的激活、金属蛋白酶组织抑制剂对基质溶素活性的调节及其病理生理学意义。
