Petrov A P, Molodtsov N V
Probl Endokrinol (Mosk). 1976;22(2):92-5.
Repeated administration of chondroitin sulfate to rats in doses of 20 and 120 mg/kg/24 hours led to reduction in the level of urinary aldosterone excretion in rats. Carboxymethylcellulose and alginic acid displayed no inhibitory effect. Urinary aldosterone excretion decreased in rats 24 hours after a single administration of chondroitin sulfate; this effect persisted for the following 3-4 days. The maximal reduction of aldosterone excretion (by 50%) occurred on the 3rd and the 4th day after administration of the preparation. Intraperitoneal injection of chondroitin sulfate to rats diminished the rate of aldosterone secretion by the adrenal glands; as to corticosterone secretion--it remained unchanged.
以20毫克/千克/24小时和120毫克/千克/24小时的剂量给大鼠重复施用硫酸软骨素，导致大鼠尿醛固酮排泄水平降低。羧甲基纤维素和海藻酸未显示出抑制作用。大鼠单次施用硫酸软骨素24小时后尿醛固酮排泄减少；这种作用在接下来的3 - 4天持续存在。施用制剂后第3天和第4天醛固酮排泄的最大减少量（达50%）出现。给大鼠腹腔注射硫酸软骨素降低了肾上腺醛固酮的分泌速率；至于皮质酮分泌——则保持不变。
