Salek-Haddadi Afraim, Lemieux Louis, Merschhemke Martin, Friston Karl J, Duncan John S, Fish David R
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, London.
Ann Neurol. 2003 May;53(5):663-7. doi: 10.1002/ana.10586.
We studied a patient with idiopathic generalized epilepsy and frequent absences, using electroencephalogram-correlated functional magnetic resonance imaging. Four prolonged runs of generalized spike-wave discharge occurred during a 35-minute experiment. Time-locked activation was observed bilaterally within the thalami in conjunction with widespread but symmetrical cortical deactivation with a frontal maximum. We demonstrate the reciprocal participation of focal thalamic and widespread cortical networks during human absence seizures and suggest reductions in cortical blood flow, in response to synchronized electroencephalogram activity.
我们使用脑电图相关功能磁共振成像技术，对一名患有特发性全身性癫痫且频繁失神发作的患者进行了研究。在35分钟的实验过程中，出现了4次持续时间较长的全身性棘波放电。在丘脑双侧观察到与时间锁定的激活，同时伴有广泛但对称的皮质失活，额叶失活最为明显。我们证明了在人类失神发作期间，局灶性丘脑和广泛的皮质网络相互参与，并表明皮质血流减少是对同步脑电图活动的反应。
