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临床应用中汉方药物的毒理学方面

Toxicological aspects of Kampo medicines in clinical use.

作者信息

Ikegami Fumio, Fujii Yuichi, Ishihara Kazuhisa, Satoh Tetsuo

机构信息

Graduate School of Pharmaceutical Sciences, Chiba University, Yayoi-cho 1-33, Inage-ku, Chiba 263-8522, Japan.

出版信息

Chem Biol Interact. 2003 Jun 15;145(3):235-50. doi: 10.1016/s0009-2797(03)00004-8.

DOI:10.1016/s0009-2797(03)00004-8
PMID:12732452
Abstract

Among 210 medicinal prescriptions used in present-day Japan, the clinical uses and the acute, chronic and mutagenic toxicity study of 16 Kampo (Japanese herbal) medicines are summarized. These Kampo medicines are classified into two categories; eight prescriptions containing Bupleurum root (Bupleurum falcatum L.) such as Sho-saiko-to and Saiko-keishi-to, and eight prescriptions not containing Bupleurum root such as Juzen-taiho-to and Ninjin-yoei-to. Studies of some potential interaction between herbal medicine and western drugs are also described.

摘要

在当今日本使用的210种药用处方中,总结了16种汉方药(日本草药)的临床用途以及急性、慢性和致突变毒性研究。这些汉方药分为两类:八味含有柴胡(Bupleurum falcatum L.)的方剂,如小柴胡汤和柴胡桂枝汤;八味不含柴胡的方剂,如十全大补汤和人参养荣汤。还描述了一些草药与西药之间潜在相互作用的研究。

相似文献

1
Toxicological aspects of Kampo medicines in clinical use.临床应用中汉方药物的毒理学方面
Chem Biol Interact. 2003 Jun 15;145(3):235-50. doi: 10.1016/s0009-2797(03)00004-8.
2
Toxicological considerations of Kampo medicines in clinical use.汉方药物临床应用的毒理学考量
Toxicology. 2004 May 20;198(1-3):221-8. doi: 10.1016/j.tox.2004.01.029.
3
Pharmacology and toxicology of Bupleurum root-containing Kampo medicines in clinical use.含柴胡的汉方制剂临床应用中的药理学与毒理学
Hum Exp Toxicol. 2006 Aug;25(8):481-94. doi: 10.1191/0960327106het654oa.
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Cheminformatics modeling of the correlation between Bupleurum Root-formula medicines and Excess and Deficiency pattern in the diagnostic criteria of Sho in Kampo (traditional Japanese medicine) by non-targeted direct infusion mass spectrometry with machine learning.采用非靶向直接进样质谱结合机器学习对《日本汉方诊疗药局方》中芍药甘草汤医方与证的相关性进行 chemoinformatics 建模
J Nat Med. 2022 Jan;76(1):306-313. doi: 10.1007/s11418-021-01577-z. Epub 2021 Oct 18.
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Inhibitory effects of Japanese herbal medicines sho-saiko-to and juzen-taiho-to on nonalcoholic steatohepatitis in mice.日本草药小柴胡汤和十全大补汤对小鼠非酒精性脂肪性肝炎的抑制作用。
PLoS One. 2014 Jan 22;9(1):e87279. doi: 10.1371/journal.pone.0087279. eCollection 2014.
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Sho-saiko-to and Saiko-keisi-to, the traditional Chinese and Japanese herbal medicines, altered hepatic drug-metabolizing enzymes in mice and rats when administered orally for a long time.小柴胡汤和柴胡桂枝汤这两种传统的中药和日本草药,长期口服给药时会改变小鼠和大鼠肝脏中的药物代谢酶。
J Pharm Pharmacol. 2003 Oct;55(10):1419-26. doi: 10.1211/0022357021873.
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The influence of traditional Chinese herbal drugs on serum 1, 5-anhydroglucitol levels.
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Expression of the anti-metastatic effect induced by Juzen-taiho-to is based on the content of Shimotsu-to constituents.十全大补汤诱导的抗转移作用的表达基于四物汤成分的含量。
Biol Pharm Bull. 1998 Jul;21(7):761-5. doi: 10.1248/bpb.21.761.
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Current status of Kampo (Japanese herbal) medicines in Japanese clinical practice guidelines.日本临床实践指南中汉方(日本草药)药的现状
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Identification of traditional Japanese Kampo medicines and crude drugs that upregulate brain‑derived neurotrophic factor in human peripheral cells.鉴定可上调人外周细胞脑源性神经营养因子的传统日本汉方药和生药。
Acta Neurobiol Exp (Wars). 2021;81(4):393-404.

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