气管插管新生儿的密闭式吸痰可维持更好的生理稳定性：一项随机试验。
Closed suctioning of intubated neonates maintains better physiologic stability: a randomized trial.
作者信息
Kalyn Angela, Blatz Susan, Paes Bosco, Bautista Carlos
机构信息
Acute Children's Services, McMaster Children's Hospital, Hamilton Health Sciences, Hamilton, Ontario, Canada.
出版信息
J Perinatol. 2003 Apr-May;23(3):218-22. doi: 10.1038/sj.jp.7210883.
OBJECTIVE
To evaluate the physiological variance in a closed (CS) vs an open suction (OS) protocol in intubated infants.
STUDY DESIGN
Infants were stratified into three weight groups in a randomized crossover trial. Heart rate, respiratory rate, blood pressure, oxygen saturation, transcutaneous oxygen and carbon dioxide, and end-tidal carbon dioxide were recorded prior to suctioning, during suctioning, and recovery to baseline. Following the procedures, recovery time to baseline parameters was measured. Data were analyzed using repeated measures ANOVA.
RESULTS
Overall, there was significantly less deviation from baseline physiological parameters with CS. Infants <1000 g had clinically significant decreases in heart rate with the OS method (-18% OS vs -6% CS; p=0.016). Recovery time in the OS group was twice that of the CS cohort (4 vs 2 minutes; p<0.001).
CONCLUSION
CS maintains better physiologic stability in intubated infants.
目的
评估插管婴儿采用密闭式（CS）与开放式吸引（OS）方案时的生理差异。
研究设计
在一项随机交叉试验中，婴儿被分为三个体重组。在吸引前、吸引期间以及恢复至基线时记录心率、呼吸频率、血压、血氧饱和度、经皮氧和二氧化碳以及呼气末二氧化碳。在操作完成后，测量恢复至基线参数的时间。使用重复测量方差分析对数据进行分析。
结果
总体而言，CS导致的生理参数与基线的偏差显著更小。体重<1000克的婴儿采用OS方法时心率出现具有临床意义的下降（OS为-18%，CS为-6%；p=0.016）。OS组的恢复时间是CS组的两倍（4分钟对2分钟；p<0.001）。
结论
CS能使插管婴儿维持更好的生理稳定性。
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