Pietrement Christine, Malot Lilia, Santerne Brigitte, Roussel Bernard, Motte Jacques, Morville Patrice
Department of Pediatrics, American Memorial Hospital, Reims, France.
J Perinatol. 2003 Apr-May;23(3):254-5. doi: 10.1038/sj.jp.7210871.
Fetal and neonatal toxic effects of angiotensin II receptor antagonists have been described in animals and humans. Five cases of fetal or neonatal deaths have been reported following maternal use of sartans for hypertension. We report a case of neonatal transient renal failure following telmisartan therapy during pregnancy. This class of antihypertensive drugs should be avoided during pregnancy and breastfeeding.
血管紧张素II受体拮抗剂对胎儿和新生儿的毒性作用在动物和人类中均有描述。有报道称，5例孕妇在使用沙坦类药物治疗高血压后出现胎儿或新生儿死亡。我们报告1例孕期使用替米沙坦治疗后出现新生儿短暂肾衰竭的病例。孕期和哺乳期应避免使用此类降压药物。
