Mohamed Faheez, Marchettini Pierre, Stuart O Anthony, Urano M, Sugarbaker Paul H
Washington Cancer Institute, Washington, DC 20010, USA.
Ann Surg Oncol. 2003 May;10(4):463-8. doi: 10.1245/aso.2003.08.006.
Hyperthermia enhances the cytotoxicity of some chemotherapeutic agents. We have studied the effect of moderate hyperthermia (41.5 degrees C) on the cytotoxicity of five new chemotherapeutic agents (docetaxel, paclitaxel, irinotecan, oxaliplatin, and gemcitabine) and melphalan against a spontaneous murine fibrosarcoma.
The tumor was an early-generation isotransplant of a spontaneous C3Hf/Sed mouse fibrosarcoma, FSa-II. Hyperthermia was administered by immersing the tumor-bearing foot into a constant temperature water bath set at 41.5 degrees C for 30 minutes when the tumor reached 34 mm(3). Chemotherapy was administered intraperitoneally immediately before hyperthermia. Tumor response was studied by the mean tumor growth time and the mean tumor growth delay time.
Hyperthermia significantly increased the tumor growth times of the animals treated with docetaxel, irinotecan, and gemcitabine at low dose and these drugs plus oxaliplatin at high dose. Docetaxel at high dose showed the greatest control of tumor growth by hyperthermia, with a 26% reduction. Concerning the taxanes, paclitaxel cytotoxicity was not enhanced by hyperthermia, but docetaxel was enhanced by hyperthermia at both doses of drug.
Moderate hyperthermia increases the cytotoxicity of docetaxel, irinotecan, and gemcitabine on mouse fibrosarcoma. Paclitaxel did not show heat enhancement. Oxaliplatin and docetaxel showed greater heat enhancement when the drug dose was high.
热疗可增强某些化疗药物的细胞毒性。我们研究了中度热疗（41.5摄氏度）对五种新型化疗药物（多西他赛、紫杉醇、伊立替康、奥沙利铂和吉西他滨）以及美法仑对自发性小鼠纤维肉瘤的细胞毒性的影响。
肿瘤为自发性C3Hf/Sed小鼠纤维肉瘤FSa-II的初代同基因移植瘤。当肿瘤体积达到34立方毫米时，将荷瘤足浸入设定为41.5摄氏度的恒温水浴中30分钟进行热疗。化疗在热疗前立即腹腔注射。通过平均肿瘤生长时间和平均肿瘤生长延迟时间来研究肿瘤反应。
热疗显著延长了低剂量多西他赛、伊立替康和吉西他滨以及高剂量这些药物加奥沙利铂治疗动物的肿瘤生长时间。高剂量多西他赛通过热疗对肿瘤生长的控制效果最佳，肿瘤生长减少了26%。关于紫杉烷类，热疗未增强紫杉醇的细胞毒性，但在两种剂量下多西他赛的细胞毒性均因热疗而增强。
中度热疗可增加多西他赛、伊立替康和吉西他滨对小鼠纤维肉瘤的细胞毒性。紫杉醇未表现出热增强作用。奥沙利铂和多西他赛在高剂量时热增强作用更强。
