Chamberlain Alexander J, Fritschi Lin, Kelly John W
Victorian Melanoma Service, Alfred Hospital, Melbourne, Victoria, Australia.
J Am Acad Dermatol. 2003 May;48(5):694-701. doi: 10.1067/mjd.2003.216.
The incidence of thick melanoma and related mortality is largely static despite advances in early detection during the last 20 years. Nodular melanoma (NM) accounts for the majority of thick lesions and is difficult to recognize in the early stages of its evolution.
The purpose of this study was to identify historic or clinical features that may facilitate earlier detection of NM.
A questionnaire was administered to 125 patients attending the Victorian Melanoma Service between 1998 and 2000 with superficial spreading melanoma or NM. Parameters were compared by tumor type and thickness.
NMs are more often symmetric, elevated, uniform in color, and nonpigmented. Color change is uncommon.
NM often fails to fulfill the ABCD diagnostic criteria. Biopsy after a set period of observation should aid differentiation from inflammatory lesions and enable earlier detection of this subtype.
尽管在过去20年早期检测方面取得了进展，但厚皮黑色素瘤的发病率和相关死亡率基本保持不变。结节性黑色素瘤（NM）占厚皮病变的大多数，并且在其演变的早期阶段难以识别。
本研究的目的是确定可能有助于早期检测NM的历史或临床特征。
1998年至2000年间，对125名前往维多利亚黑色素瘤服务中心就诊的患有浅表扩散性黑色素瘤或NM的患者进行了问卷调查。通过肿瘤类型和厚度对参数进行比较。
NM更常表现为对称、隆起、颜色均匀且无色素沉着。颜色变化不常见。
NM通常不符合ABCD诊断标准。经过一段观察期后进行活检应有助于与炎性病变相鉴别，并能更早地检测出这种亚型。
