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乳酸输注对人体葡萄糖和游离脂肪酸代谢的影响。

Influence of lactate infusion on glucose and FFA metabolism in man.

作者信息

Ahlborg G, Hagenfeldt L, Wahren J

出版信息

Scand J Clin Lab Invest. 1976 Mar;36(2):193-201. doi: 10.1080/00365517609055248.

DOI:10.1080/00365517609055248
PMID:1273497
Abstract

Sodium L(+)-lactate was infused at rates of 5 to 12 mmol/min intravenously for 30 min in health volunteers, and the exchange of lactate, glucose, and free fatty acids (FFA) was measured in the leg, the forearm muscle, and the splanchnic region. Arterial lactate levels were 3 to 5 mmol/l during the infusion. Leg blood flow increased about 2.5-fold and leg oxygen uptake rose by 35%. Blood flow, oxygen uptake, and glucose production in the splanchnic area remained unaltered. The fractional uptake of lactate by the leg, the splanchnic region, and the forearm decreased during the course of the infusion.

摘要

在健康志愿者中,以5至12毫摩尔/分钟的速率静脉输注L(+)-乳酸钠30分钟,然后测定腿部、前臂肌肉和内脏区域中乳酸、葡萄糖和游离脂肪酸(FFA)的交换情况。输注过程中动脉乳酸水平为3至5毫摩尔/升。腿部血流量增加约2.5倍,腿部摄氧量增加35%。内脏区域的血流量、摄氧量和葡萄糖生成量保持不变。在输注过程中,腿部、内脏区域和前臂对乳酸的摄取分数下降。

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