Mahley R, Nelson A W, Ferrans V J, Fry D L
Science. 1976 Jun 11;192(4244):1139-41. doi: 10.1126/science.1273587.
The distribution, severity, and complications of diet-induced atherosclerosis in dogs can be altered by changing the source of fat in the diet. Thrombosis and thromboembolic disease associated with atherosclerosis occurred with diets containing beef tallow and lard of coconut oil but were absent in dogs fed cottonseed oil as a source of fat. Experiemtnal animals with and without thrombosis are of value as models in elucidating the role of platelets and thrombostatic mechanisms in atherosclerosis.
通过改变饮食中的脂肪来源，可以改变犬类饮食诱导的动脉粥样硬化的分布、严重程度和并发症。与动脉粥样硬化相关的血栓形成和血栓栓塞性疾病在含有牛脂和椰子油猪油的饮食中出现，但在以棉籽油作为脂肪来源的犬类中不存在。有血栓形成和无血栓形成的实验动物作为模型，在阐明血小板和止血机制在动脉粥样硬化中的作用方面具有价值。
