Cavirani S, Fanti F, Benecchi M, Calderaro A, Taddei S, Arcangeletti C, Medici M C, Dettori G, Chezzi C
Dipartimento di Salute Animale, Sezione di Malattie Infettive degli Animali - Università degli Studi di Parma.
New Microbiol. 2003 Apr;26(2):181-6.
Susceptibility of Mycobacterium bovis strains to antituberculous drugs (isoniazid and rifampin) was detected by radiometric BACTEC 460TB system. M.bovis strains were isolated from tissue samples showing tuberculous lesions collected at an abbattoir from cattle belonging to 47 tuberculosis outbreaks occurring in Northern Italy in 1995-1999. Forty-six out of 61 strains (75.4%) resulted susceptible to both isoniazid and rifampin. Thirteen strains (21.3%) were resistant to isoniazid only. No strains showed resistance to rifampin only. Two strains (3.3%) resulted resistant to both drugs, showing antituberculous multidrug-resistance. Given the compulsory eradication program of bovine tuberculosis by elimination of infected animals and the ban on antituberculous drug treatments in animals, detection of resistant M. bovis strains appears of great interest.
采用放射性BACTEC 460TB系统检测牛分枝杆菌菌株对抗结核药物（异烟肼和利福平）的敏感性。牛分枝杆菌菌株从1995 - 1999年意大利北部47起结核病爆发的牛群中，在屠宰场采集的显示结核病变的组织样本中分离得到。61株菌株中有46株（75.4%）对异烟肼和利福平均敏感。13株（21.3%）仅对异烟肼耐药。没有菌株仅对利福平耐药。2株（3.3%）对两种药物均耐药，表现出耐多药结核病。鉴于通过扑杀感染动物对牛结核病实施强制根除计划以及禁止对动物进行抗结核药物治疗，检测耐药牛分枝杆菌菌株显得非常重要。
