Kadyrov Renat, Riermeier Thomas H, Dingerdissen Uwe, Tararov Vitali, Börner Armin
Degussa AG, Project House Catalysis, Industriepark Höchst, G 830, D-65926 Frankfurt/Main, Germany.
J Org Chem. 2003 May 16;68(10):4067-70. doi: 10.1021/jo020690k.
High-throughput screening considering a library of 96 chiral P-ligands involved in two types of Rh(I) complexes was used for the identification of homogeneous catalysts for the highly enantioselective reductive amination of alpha-keto acids with benzylamine. After optimization of the reaction conditions and scale-up with a cationic Rh-Deguphos catalyst, a range of chiral alpha-amino acids could be produced by this new reaction in good yield and by up to 98% ee.
通过高通量筛选，研究了96种参与两种铑（I）配合物的手性磷配体库，用于鉴定α-酮酸与苄胺的高对映选择性还原胺化反应的均相催化剂。在用阳离子铑-德古磷催化剂优化反应条件并放大规模后，通过这种新反应可以以良好的产率和高达98%的对映体过量（ee）制备一系列手性α-氨基酸。
