Khakoo Salim I, Brooks Collin R
Division of Infection Inflammation and Repair, School of Medicine, University of Southampton, Mailpoint 811, Southampton General Hospital, Tremona Road, Southampton SO16 6YD, UK.
Clin Sci (Lond). 2003 Aug;105(2):127-40. doi: 10.1042/CS20030095.
The functions of natural killer (NK) cells are controlled by an abundance of activating and inhibitory receptors. Many of these interact with MHC class I molecules. The MHC system also interacts with cytotoxic T-lymphocytes and has been shown to comprise a rapidly evolving family of molecules. This challenges the functional relationship of NK cell receptors with their ligands. Although individual receptors have become subject to species-specific expansions over evolutionary time, the main themes of the NK cell interaction with MHC class I have been preserved. This review details the interaction of NK cell receptors with MHC class I and discusses their unexpectedly rapid evolution.
自然杀伤（NK）细胞的功能受大量激活受体和抑制受体的调控。其中许多受体与MHC I类分子相互作用。MHC系统还与细胞毒性T淋巴细胞相互作用，并且已被证明包含一个快速进化的分子家族。这对NK细胞受体与其配体之间的功能关系提出了挑战。尽管在进化过程中个别受体出现了物种特异性的扩增，但NK细胞与MHC I类分子相互作用的主要模式得以保留。本综述详细阐述了NK细胞受体与MHC I类分子的相互作用，并讨论了它们出人意料的快速进化。
