van Arman G G, Campbell W C
Tex Rep Biol Med. 1975;33(2):303-11.
In 6 differnet animal assays in the laboratory, thiabendazole had clear anti-inflammatory effect, though it was less potent than aspirin in all assays. These findings add support to clinical suggestions that the drug may have anti-inflammatory properties in man. Such properties may contribute to the clinical response observed following the use of thiabendazole in cases of trichinosis, cutaneous larva migrans, visceral larva migrans, dracunculosis and scabies. In parasitic infections in which corticosteroids are commonly used in clinical management, notably trichinosis, the fact that thiabendazole does not appear to have immunosuppressive activity may confer an added clinical advantage.
在实验室的6种不同动物试验中，噻苯达唑具有明显的抗炎作用，尽管在所有试验中其效力均低于阿司匹林。这些发现为该药物可能对人类具有抗炎特性的临床建议提供了支持。这些特性可能有助于解释在旋毛虫病、皮肤幼虫移行症、内脏幼虫移行症、麦地那龙线虫病和疥疮病例中使用噻苯达唑后观察到的临床反应。在临床治疗中通常使用皮质类固醇的寄生虫感染中，尤其是旋毛虫病，噻苯达唑似乎没有免疫抑制活性这一事实可能会带来额外的临床优势。
