Prignitz R, Hoffmeister N, Hoffmeister G
Strahlentherapie. 1975 Jun;149(6):621-7.
The behavior of enzyme activities, substrates and metabolites of glycosis as well as of the pentose phosphate shunt following local irradiation (250 to 6000 R surface dose) is biochemically investigated in the guinea-pig's myocardium. During irradiation, an activation of phosphorylase-a is going on while the total phosphorylase content remains unchanged. Enzyme activities of hexokinase and phosphofructokinase are increased in dependence on dosage as well as time. The glycogen content is being reduced; tissular concentration of the metabolites glucose-1-phosphate, glucose-6-phosphate, glyceraldehyde-3-phosphate, glycerol-3-phosphate, and pyruvate increases following irradiation; the content of fructose-1,6-diphosphate, dihydroxyacetonephosphate, and lactate is decreased. The activity of glucose-6-phosphate dehydrogenas is slightly inhibited, whereas 6-phosphogluconate-dehydrogenase remains unaffected.
在豚鼠心肌中对局部照射（表面剂量250至6000伦琴）后糖酵解以及磷酸戊糖途径的酶活性、底物和代谢产物的行为进行了生化研究。在照射期间，磷酸化酶-a发生激活，而总磷酸化酶含量保持不变。己糖激酶和磷酸果糖激酶的酶活性随剂量和时间增加。糖原含量减少；照射后代谢产物1-磷酸葡萄糖、6-磷酸葡萄糖、3-磷酸甘油醛、3-磷酸甘油和丙酮酸的组织浓度增加；1,6-二磷酸果糖、磷酸二羟丙酮和乳酸的含量降低。6-磷酸葡萄糖脱氢酶的活性略有抑制，而6-磷酸葡萄糖酸脱氢酶未受影响。
