兴奋通过内源性大麻素减少抑制作用。

Excitement reduces inhibition via endocannabinoids.

作者信息

Freund Tamás F, Hájos Norbert

机构信息

Department of Functional Neuroanatomy, Institute of Experimental Medicine, Hungarian Academy of Sciences, H-1450, Budapest, Hungary.

出版信息

Neuron. 2003 May 8;38(3):362-5. doi: 10.1016/s0896-6273(03)00262-9.

DOI:10.1016/s0896-6273(03)00262-9

PMID:12741983

Abstract

Previous work has suggested a role for retrograde synaptic signaling via endogenous cannabinoids in regulating the inhibitory control of neuronal activity. In this issue of Neuron, Chevaleyre and Castillo provide evidence for another form of endocannabinoid-mediated depression of hippocampal inhibition, which is activity dependent and long lasting.

摘要

先前的研究表明，内源性大麻素介导的逆行突触信号在调节神经元活动的抑制性控制中发挥作用。在本期《神经元》杂志中，谢瓦莱尔和卡斯蒂略提供了证据，证明内源性大麻素介导的海马抑制作用的另一种形式，这种形式依赖于活动且持续时间长。